Researchers created a functioning mini-human liver and successfully transplanted it into rats.
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RESTRICTIONS: Broadcast: NO USE JAPAN, NO USE TAIWAN Digital: NO USE JAPAN, NO USE TAIWAN Researchers created a functioning mini-human liver and successfully transplanted it into rats.
According to a report published in Cell Reports, experts from the University of Pittsburgh successfully developed and transplanted functioning human mini-livers into rats.
Scientists created the mini livers by using human skin cells and then reverting them into a stem cell state.
These cells are called induced pluripotent stem cells and other types of cells can derive from them.
They then used chemicals and hormones to induce differentiation.
This pushed the induced pluripotent stem cells into becoming liver cells.
The newly created liver cells were then seeded on mini-liver bioreactors.
The lab-grown livers were then transplanted into five immunosuppressed mice or mice whose immune system would be less likely to reject the organ.
Four days after the transplant, the mice were dissected in order to examine how well the implanted organ functioned.
After dissecting the rats, researchers found all five rats had blood circulation issues around the graft of the mini-liver.
However, the rats had human liver proteins in their blood serum indicating that the livers were working properly.
RUNDOWN SHOWS: 1.
Human liver in a laboratory rat 2.
Human cells harvested and turned into stem cells 3.
Stem cells become liver cells and are then put into rat livers 4.
Human mini livers in mice / Scientist dissecting a mouse VOICEOVER (in English): "According to a report published in Cell Reports, experts from the University of Pittsburgh successfully developed and transplanted functioning human mini-livers into rats." "Scientists created the mini livers by using human skin cells and then reverting them into a stem cell state." "These cells are called induced pluripotent stem cells and other types of cells can derive from them." "They then used chemicals and hormones to induce differentiation.
This pushed the induced pluripotent stem cells into becoming liver cells." "The newly created liver cells were then seeded on mini-liver bioreactors." "The lab-grown livers were then transplanted into five immunosupressed mice or mice whose immune system would be less likely to reject the organ." "Four days after the transplant, the mice were dissected in order to examine how well the implanted organ functioned." SOURCES: Cell Reports https://www.cell.com/cell-reports/pdf/S2211-1247(20)30688-4.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124720306884%3Fshowall%3Dtrue *** For story suggestions please contact tips@nextanimation.com.tw For technical and editorial support, please contact: Asia: +61 2 93 73 1841 Europe: +44 20 7542 7599 Americas and Latam: +1 800 738 8377
PITTSBURGH — Researchers created a functioning mini-human liver and successfully transplanted it into rats.
According..