The first single from Santana IV, entitled "Anywhere You Want to Go", was released on February 5, 2016.
The album reunited most of the surviving members from the early 1970s lineup of the band (including Carlos Santana, Gregg Rolie, Neal Schon, Mike Carabello and Michael Shrieve) and was the first time that the quintet had recorded together since 1971's Santana III.